Endocrine Abstracts

Introduction: The emergence of a new generation of antidiabetic drugs (GLP-1RA and SGLT-2i) with complementary mechanisms of action offer new alternatives in the treatment of patients with T2D and poor metabolic control.Objectives: To evaluate the efficacy of the aGLP-1 and iSGLT2 combination on metabolic control, weight, blood pressure and insulin dose in patients with DM2.Methods: Observational, retrospective study. We studied T2...

Introduction: Ghrelin is an orexigenic hormone with two isoforms: Acyl Ghrelin (AG) and Desacyl Ghrelin (DAG). AG binds to its specific receptor GHS-R1 and stimulates growth hormone secretion. DAG also binds to GHS-R1 receptor, but with 1000 times less affinity than AG. Effect of DAG on cell proliferation and inhibition of apoptosis has been reported. However, there are no studies of DAG function in human placenta. For first time, this work analyzed the effect of DAG on viabil...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) can present a high morbi-mortality.Initial subtype identification facilitates appropriate management.We describe the utility of diagnostic tests in a cohort of patients with AIT.Material and methods: Retrospective, observational study of 59 patients attended from 2007 to 2018 in outpatient clinic. Differential diagnosis: type I if FT4 and FT3 (TH) were normalized following therapy with antithyroid dru...

Aims: A few studies have shown disturbances in the hypothalamic-pituitary-adrenal (HPA) axis in chronic-kidney-disease (CKD), of unknown extent and clinical implications. We aimed to study the HPA axis in patients with CKD and its association with kidney impairment and metabolic disturbances.Methods: Cross-sectional controlled study. Patients with CKD stages I-II (estimated glomerular filtration rate [eGFR] through CKD-EPI equation >60), stage III (e...

Introduction: Prevalence of vitamin D deficiency is relatively high worldwide, it is associated with poor skeletal health and has recently been related to other extra-skeletal diseases, probably due to its immunomodulatory effects. Detection and treatment of asymptomatic hypovitaminosis D in healthy adult population is especially relevant to attempt to optimize the overall functioning of the human body.Objectives: To assess the percentage of adult health...

Introduction: Terlipressin is a non-selective vasopressin analogue used in patients with decompensated cirrhosis, gastrointestinal haemorrhage or hepatorenal syndrome. It directly binds to V1 receptors improving circulatory volume by causing splanchnic vasoconstriction and portal hypertension inhibition, and has a full V2 receptor agonism in the collecting duct. In consequence, it increases reabsorption of water and can lead to a decrease in plasma osmolality and hyponatremia....

Introduction: Differentiated thyroid cancer (DTC) represent 85- 90 % of all thyroid cancer cases. Most of these have an excellent prognosis with standard treatment. However, between 7 and 23% will develop distant metastases and, of these, more than 65% will become radioactive iodine-refractory. In some of these patients who are considered to be radioiodine-refractory with rapidly progressive or symptomatic disease, or in patients who are not candidates for other therapies, the...

Introduction: The most frequent causes of ACTH-dependent Cushing’s syndrome are of pituitary origin and, less frequently, due to ectopic secretion of bronchial carcinoid, small cell lung cancer, and neuroendocrine tumors; it is rarely caused by an ACTH-producing pheochromocytoma.Methodology: We present a case of a 44-year-old female with a history of poorly controlled type 2 diabetes, hypertension, and long-standing obesity with no genetic predispos...

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

Introduction: Hyponatremia (HN) is associated with worse clinical outcomes, and longer hospital lengths-of-stay than seen in eunatremic patients. The Syndrome of Inappropriate Antidiuresis (SIAD) is the most common cause of hyponatremia in hospitalization. We studied the relationship between correction of sustained SIAD-induced hyponatremia and visits to the Emergency Room (ERv) as well as hospital admissions (HA) in a case series.Methods: Retrospective,...